2-Month Vaccine: What You Should Know

Having a 2-month-old is an exciting time filled with developmental milestones. Your baby may start to coo, smile, and notice their hands. Regular health checks are important to ensure your baby’s health, growth and development are on track.

Babies are usually scheduled to be vaccinated at their 2-month health check. This article discusses recommended vaccinations, possible side effects, and how to reassure babies during and after their visit.

2 month milestone

Here are the milestones that 2-month-old babies often reach:

  • smile and mumble
  • put hand to mouth
  • a brief period of calm
  • Pay more attention to faces
  • turn head to sound
  • Begins to act bored (becomes irritable if activity doesn’t change)
  • Raise your head when lying down

2 months of vaccinations

While babies are born with fairly strong immune systems, some diseases can be severe and difficult to fight on their own. Vaccinations are done to help their immune systems prevent these diseases.

The Centers for Disease Control and Prevention (CDC) recommends an immunization program that includes six vaccinations for infants as young as 2 months old.

Most vaccines are given as injections. However, rotavirus vaccine (RV) is administered orally via droplets.

Alternative Names for Vaccines

Vaccination may also be called:

  • inoculate
  • injection
  • shooting
  • vaccine
  • immunity

comfort your baby

During the appointment, you can help your baby by:

  • hold them
  • distract them with toys or singing
  • Smile and whisper reassuring words

After your appointment, you can soothe your baby by:

  • breastfeeding or bottle feeding
  • Provide a pacifier
  • swaddled in their favorite blanket
  • Give them Tylenol (acetaminophen) as needed for pain

How much Tylenol does your child need?

Diphtheria, Tetanus, Acellular Pertussis (DTaP)

The DTaP vaccine is given in five doses. The first dose is started at 2 months of age and the last dose is started at 4-6 years of age. DTaP helps prevent the following diseases:

  • diphtheria
  • tetanus
  • pertussis (pertussis)

Is it DTaP or Tdap?

Both DTaP and Tdap are vaccines that protect against the same disease. The first five doses given were DTaP. Tdap is a booster for 11 or older.

How the DTaP Vaccine Helps Prevent Infectious Diseases

Haemophilus influenzae type B (Hib)

Haemophilus influenzae Type B (Hib) is often confused with seasonal influenza (flu) because of their similar names. However, these are two different diseases. Seasonal flu is a virus, while Hib is a bacteria that can cause:

  • meningitis
  • pneumonia (lung infection)
  • sepsis (bloodstream infection)
  • Epiglottitis (swelling of the upper airway or windpipe)

Hib Statistics

From 1989 to 2000, Hib infection rates in the United States fell by 99% due to vaccination.

Polio vaccine (IPV)

In the late 1940s, polio was a highly feared disease that caused paralysis. After the polio vaccine, the number of infections in the U.S. dropped sharply.

Children in the United States receive a vaccine called inactivated polio vaccine (IPV). Other countries may use oral polio vaccine (OPV).

IPV is administered in four doses at the following ages:

  • 2 months
  • 4 months
  • 6-18 months
  • 4-6 years

Polio cases in the United States

There have been no cases of polio in the United States since 1979. In 1993, one case entered the United States through travel. Healthcare providers may choose to expedite polio vaccination for children traveling to high-risk countries.

Pneumococcal Conjugate Vaccine (PCV)

This pneumococcal conjugate The vaccine (PCV) protects against bacterial infections that cause ear or sinus infections, meningitis, and pneumonia.

The PCV vaccine is given in four doses at the following ages:

  • 2 months
  • 4 months
  • 6 months
  • 12-15 months

pneumococcal disease

Streptococcus pneumoniae or pneumococcus is the bacteria that causes pneumococcal disease. Immunization against these diseases is important because they can be aggressive and severe.

Hepatitis B (HBV)

Hepatitis B is a potentially serious viral infection that can cause liver damage. It is passed on through bodily fluids or from mother to baby. Hepatitis B vaccine (HBV) is given in three doses at the following ages:

  • shortly after birth
  • 1-2 months
  • 6-18 months

Protecting your baby from hepatitis B after giving birth

Mothers can contract hepatitis B without symptoms and pass it on to their babies unknowingly at birth. This is why babies usually receive their first dose within the first 12 hours of their life.

Rotavirus (RV)

Rotavirus (RV) is a gastrointestinal virus that causes stomach pain, severe vomiting, diarrhea, and dehydration (loss of body fluids). The RV vaccine is given as a drop into the mouth.

There are two brands of this vaccine. One brand was given at 2 and 4 months old. Another brand includes a third dose given at 6 months of age.

side effect

If a baby has side effects after a vaccination, it is usually mild.

The most common side effects include:

  • pain, redness, or swelling at the injection site
  • Low-grade fever (100-102 degrees or lower)

Less common side effects include:

  • irritability or irritability
  • loss of appetite
  • diarrhea or vomiting

What about serious side effects?

Serious side effects or allergic reactions are very rare. If you are concerned about this possibility, please consult your healthcare provider before making an appointment.

What to do if your baby has side effects

To help reduce mild reactions, you can try the following:

  • Cool cloth to reduce redness and swelling
  • Room temperature sponge bath for low fever
  • Feed your baby more often for comfort and hydration
  • Give Tylenol (acetaminophen) if approved by your pediatrician

Medications to reduce fever and discomfort

Motrin or Advil (ibuprofen) are not usually used in babies younger than 6 months. Tylenol (acetaminophen) is safe for infants 2 months old and older and approved by your healthcare provider. Children should not receive aspirin unless directed by a healthcare provider.

When to contact a pediatrician

Contact their healthcare provider if your baby has any of the following symptoms:

  • Fever over 104 degrees
  • Redness at the injection site greater than 1 inch or lasting more than 3 days
  • High-pitched cries lasting more than an hour
  • Crying for three hours or more
  • irritability for more than three days
  • severe vomiting or diarrhea

When to call 911

Call 911 right away if you think your baby has a life-threatening emergency or any of the following rare reactions:

  • Difficulty breathing
  • hard to swallow
  • drowsiness (not moving or very weak)
  • did not wake up
  • Seizures

Could a baby have a fatal reaction to a vaccine?


Babies are usually vaccinated at their 2-month-old health check to help protect them from preventable diseases. You can hold your baby and give them their favorite blanket, pacifier, or toy to help comfort them. Side effects from vaccination are usually mild and can be treated at home to relieve any discomfort.

VigorTip words

Parents often worry that their babies will respond to vaccinations. Although mild reactions to vaccinations may occur, severe reactions are very rare. If you have any concerns, don’t be ashamed to speak with your healthcare provider. Overall, the benefits of getting vaccinated (and getting vaccinated early in life) far outweigh the risks.

What baby injections does my child need?

Frequently Asked Questions

  • How much baby Tylenol is recommended after 2 months of vaccination?

    For infants younger than 3 months old, it is best to get your healthcare provider’s approval before giving Tylenol (acetaminophen). Once approved, the dose will be based on a concentration of 160 mg Tylenol per 5 ml. For infants weighing 6-11 pounds, the usual dose is 1.25 ml.

    understand more:

    What is a safe dose of Tylenol for babies?

  • How do I prepare vaccines for my 2-month-old?

    Write down your questions and take available shot records with you. It’s also helpful to pack your baby’s favorite toy, pacifier, or blanket to comfort them during visits.