According to nutritionists, the 9 best supplements for depression in 2021

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In 2017, approximately 17.3 million adults aged 18 or over in the United States experienced at least one major depression last year (7.1% of American adults).There are many options for treating depression, including treatments, medications, and complementary and alternative treatments.

Depression is a serious mental disorder and it is important to cooperate with a mental health professional when seeking help. Research on how dietary supplements and herbs can reduce depression is still emerging. For patients diagnosed with depression, therapeutic interventions should be explored first, and supplements should be used in combination with treatment and possible drugs.

It is important to remember that there is no single panacea for mental health disorders, and you may benefit the most from various supports. Before taking a new supplement, consult your healthcare team.

Here are the best supplements for depression:

Final verdict

Vitamins, minerals and antioxidants work best when combined with each other. When it comes to brain health, no single nutrient is supreme. For this reason, Pure Encapsulations Multivitamin is our top choice for the best depression supplement. It is a good choice for both men and women. We like Pure Encapsulations to prioritize purity, potency and cleansing ingredients.

What to look for in supplements for depression

raw material

Supplements for depression vary in strength, formulation, and composition; there is no one size fits all when it comes to choosing the right supplement for you. Research on the best types of depression supplements is mixed, so it may take trial and error to find the best product for you.

It is important to check the ingredients when buying a new supplement. Please be aware of potential allergens, and if you are not sure about the supplement ingredients in the product, be sure to contact your healthcare provider.

Not all supplements are created equal. It is worth spending a little more money to buy products from a company that puts quality and purity first. Look for certifications from independent third-party testing companies (such as and NSF International). These organizations provide quality testing and allow products that pass the test to display a quality assurance seal, indicating that the product is manufactured correctly, contains the ingredients listed on the label, and does not contain harmful levels of contaminants.


Although most of the supplements reviewed are generally considered safe, if you are already taking certain medications or supplements, you may need to consult your healthcare provider. It is important to remember that just because the supplement is derived from natural ingredients, it can still be very powerful. Start a new supplement at the lowest possible dose, pay attention to unwanted changes, and increase as needed.

Frequently asked questions

  • Can I take natural supplements with my prescription depression medicine?

    Depression is a serious mental health disorder that may involve multiple forms of treatment, including treatment, prescription drugs, lifestyle changes, and possible supplements. Some supplements may be safe to use with prescription drugs, while others may be unsafe.

    If supplements are known to affect serotonin levels and you are taking a selective serotonin reuptake inhibitor (SSRI), combining the two may be dangerous. Some nutritional supplements, such as vitamins or omega-3 fatty acids, are generally considered safe. Before adding supplements to ensure safety, consult your prescription provider.

  • Which supplement is best for seasonal depression or SAD?

    Depending on where you live, it may be wise to take vitamin D supplements during the winter. When there is less sunlight or more time indoors due to cold, we may be deficient in vitamin D.

    Taking a multivitamin in the winter may also make sense, as dietary intake tends to fluctuate according to the season. Multivitamins can ensure that all your nutritional bases are covered.

  • Which supplement is best for boosting mood?

    Research on the role of natural supplements in the treatment of depression is so new that it is difficult to make a clear statement about which supplement is best as a mood booster. Certain probiotics may help regulate mood or recover from sadness. In addition, adaptogens like Rhodiola may help support emotions in stressful situations.

What the experts say

“The treatment of depression is multifaceted, and interventions should be targeted at individual patients. Some supplements such as omega-3 fatty acids may be helpful, but they should not be the main form of treatment.” —Dr Robin Shore

Why trust is very good thinking?

As a registered dietitian, Sydney Greene takes supplement recommendations seriously. Each product has been researched and reviewed by her for clinical research, product reviews and third-party testing websites. These products not only made her feel comfortable recommending to her customers, but she would take them by herself when needed.