Can I take aspirin and ibuprofen at the same time?

If you have certain conditions, your doctor may recommend daily aspirin.However, if you also want to take ibuprofenpain relievers under the brand names Motrin and Advil, and you may be wondering how risky the two are if you take them together.

This article explains whether it is safe to mix aspirin and ibuprofen. It will also discuss other considerations when taking more than one drug at a time.

Is it safe to take aspirin and ibuprofen together?

Because aspirin is a blood thinner, your doctor may recommend it to help treat conditions involving blood clots, which occur when blood clots together. For example, it may help prevent heart attacks, which occur when blood flow to the heart is blocked. It may also help prevent strokes, which occur when blood supply to the brain is reduced. Ibuprofen can interfere with the blood-thinning or anticoagulant effects of low-dose aspirin.

Consider the following:

  • If you use ibuprofen occasionally, there is a small risk of it interfering with the effects of low-dose aspirin.
  • If you need a single dose of ibuprofen, take it 8 hours before or 30 minutes after your regular, uncoated, unsustained-release low-dose aspirin.
  • If you need to take ibuprofen more often, talk to your healthcare provider about alternative medicines.
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Ibuprofen belongs to a class of drugs called NSAIDs or non-steroidal anti-inflammatory drugs. You should not take another NSAID without talking to your healthcare provider, as they may also interfere with the effects of low-dose aspirin.


Ibuprofen can interfere with the blood-thinning effects of aspirin. However, taking ibuprofen occasionally is considered low risk. If you’re not sure, be sure to check with your doctor before taking both.

Can ibuprofen be taken with low dose aspirin?

What happens if you mix ibuprofen and high-dose aspirin?

The FDA’s recommendation for mixing ibuprofen and aspirin is for low-dose aspirin only.

The ability of ibuprofen to interfere with the blood-thinning effects of coated aspirin or high-dose aspirin is unknown.

To be safe, if you are also using aspirin, be sure to consult your healthcare provider or pharmacist, who is a medication specialist, before taking any over-the-counter pain relievers.

What happens if you take aspirin every day?

Health care providers sometimes recommend taking low-dose daily aspirin to help reduce the risk of certain heart diseases. However, aspirin can cause side effects in some people, such as an upset stomach and certain types of bleeding.

For those aged 40 to 70, daily aspirin is recommended:

  • No current heart disease
  • no bleeding risk
  • risk of heart disease in the next 10 years

Benefits and risks of aspirin therapy

Can you take ibuprofen and acetaminophen at the same time?

ibuprofen and Acetaminophenor Tylenol, can be mixed.

In fact, studies have shown that taking ibuprofen and acetaminophen together in a combination formula called Maxigesic can provide better pain relief in oral surgery patients than either ibuprofen or acetaminophen alone.


Your doctor may recommend that you take aspirin every day to prevent certain conditions that involve blood clots, such as heart attack or stroke. However, keep in mind that taking ibuprofen along with aspirin may interfere with the anti-clotting effects of aspirin.

While aspirin and ibuprofen may not work well together, ibuprofen can be safely taken with acetaminophen. Always consult your doctor or pharmacist before mixing any over-the-counter medicines.