Can you take Tylenol and meloxicam?

Meloxicam (Mobic) is a non-steroidal anti-inflammatory drug (NSAID) used to treat arthritis.Tylenol is the most common brand of pain reliever known as Acetaminophen. It is also used to relieve arthritis pain, especially if NSAIDs are not sufficient to eliminate the pain. Usually, you can take both medicines at the same time without problems.

This article explains how the two drugs compare to each other and how to take them together safely. It also covers what you need to know about the risks of taking too much of either.

Meloxicam and Tylenol

Although both meloxicam and Tylenol are used to treat pain, they differ in some ways. Best of all, Tylenol can be purchased over the counter without a prescription. Meloxicam should only be used with a doctor’s prescription.

You usually take different doses of each medicine. Meloxicam is available in doses of 7.5 milligrams (mg) or 15 mg once a day. Tylenol comes in a variety of benefits – from 325 mg of regular Tylenol to 650 mg of Tylenol for 8-Hour Arthritis Pain. The amount you take and how often you take Tylenol depends on the strength of the product.

The most effective Tylenol for your symptoms

How they can help you manage your pain

Tylenol and meloxicam belong to different drug classes and work differently.

The role of non-steroidal anti-inflammatory drugs

NSAIDs like meloxicam relieve pain by blocking an enzyme cyclooxygenase, or COX. In your body, enzymes control chemical reactions that help you do things like digest food. COX enzymes play a role in inflammation, which is a symptom of arthritis. By blocking COX enzymes, NSAIDs can prevent inflammation and relieve some of the discomfort caused by arthritis.

The effect of acetaminophen

Tylenol is a type of acetaminophen that belongs to a class known as pain relieverAlthough researchers don’t fully understand how acetaminophen works in the body, it is believed to block the formation of COX enzymes in the central nervous system.

So, while both NSAIDs and acetaminophen act on the COX enzyme to reduce pain, they differ in how and where they block the enzyme. They are equally effective in pain. However, meloxicam reduces inflammation in the body while Tylenol does not.

Is it safe to take meloxicam with Tylenol?

It is safe to take meloxicam and Tylenol because there are no known drug interactions between the two drugs. However, it is important to remember to follow the recommended daily dose of each drug. Dangerous side effects may occur if you take more than one dose of one or the other.

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Some of the side effects that may occur if you take too much Tylenol include:

  • nausea
  • Vomit
  • loss of appetite
  • sweat
  • extremely tired
  • unusual bleeding or bruising
  • upper right stomach pain
  • yellowing of the skin or eyes
  • flu-like symptoms

When it comes to meloxicam, taking too much can also have some harmful health effects. They include:

  • energy shortage
  • drowsiness
  • nausea
  • Vomit
  • stomachache
  • Bloody, black or tarry stools
  • Vomit that is bloody or looks like coffee grounds
  • Difficulty breathing
  • Seizures
  • coma

An overdose of either drug can cause liver damage. In the case of Tylenol, the liver breaks down the drug into individual parts. The part used to help relieve pain remains in the body.

At the same time, unwanted parts are excreted through urine.Unnecessary parts include toxic substances (called N-Acetyl-p-benzoquinoneimine). If you ingest too much Tylenol, your body won’t be able to clear the toxins out fast enough. It builds up in the liver and causes liver damage.

With meloxicam, the cause of liver damage is not known, but it can still occur in rare cases.

Arthritis pain relievers: strongest to weakest


Meloxicam is a non-steroidal anti-inflammatory drug that can be taken alone or with other medications to treat pain and inflammation associated with arthritis. Tylenol, also known as acetaminophen, is an analgesic pain reliever that can be added to your treatment plan to help manage pain when NSAIDs alone aren’t enough. These drugs are safe to take together, but you must be careful not to take more than the recommended dose of each drug.

NSAIDs warning

If prescribed for pain, NSAIDs such as meloxicam are usually meant for short-term use. In fact, it is usually not used for more than 10 consecutive days. Sometimes your doctor will prescribe longer NSAIDs, but these are special cases your doctor will outline for you.

Taking NSAIDs increases the risk of heart attack and stroke. The risk is higher when the drug is taken in higher doses and for a longer period of time. In some cases, the risk of these problems also increases when you first start taking the medicine. If you already have heart disease, you have a greater chance of having a serious reaction. However, you can have a heart attack or stroke even if you have no history of heart disease.

NSAIDs may also cause stomach and intestinal disorders, such as ulcers or stomach bleeding. Older adults, people with a history of stomach ulcers, people who take blood thinners, people who drink alcohol every day, and people who take more than one prescription or over-the-counter NSAID at a time are at higher risk for these problems.

What You Should Know About NSAIDs for Arthritis

serious side effects

In some cases, serious side effects can occur while taking regular doses of meloxicam. Your healthcare provider should address the following symptoms right away:

  • Gastrointestinal problems, such as black stool, blood or cloudy urine, severe stomach pain, vomit that looks like coffee grounds, changes in urination, unusual weight gain, or jaundice
  • Head problems, such as blurred vision, ringing in the ears, sensitivity to light, severe headaches, trouble speaking or thinking, or changes in balance
  • Fluid retention that manifests as swelling of the mouth, face, lips, tongue, ankles, feet, legs, or hands
  • signs of an allergic reaction, such as a rash or hives, red peeling, itching, or trouble breathing
  • unexplained bruising or bleeding
  • chest problems, such as pain, fast or fast heartbeat, and palpitations
  • Flu-like symptoms with acute fatigue
  • unbearable back pain


Meloxicam is usually used for short-term use. If you take more than the recommended dose, you may be at risk of heart attack, stroke, stomach problems, or liver damage. This can happen if you take more than one NSAID at a time, or if you take too much meloxicam for too long. Drinking alcohol, taking blood thinners, or having a history of ulcers can increase the likelihood of serious problems. Taking it as directed, you may still experience some side effects that should be discussed with your doctor.

Acetaminophen warning

Taking too much acetaminophen can cause serious liver damage, especially when taken with other drugs that can damage the liver. Drinking alcohol while taking acetaminophen can also increase your risk of liver damage.

It is also possible to have an allergic reaction to Tylenol. Signs of an allergic reaction include reddened skin, blisters, and a rash. Avoid other medicines that contain acetaminophen while using Tylenol. You also should not take medicine for more than 10 days for pain relief or three days for fever relief. Take no more than 3 grams of acetaminophen per day (the recommended maximum daily dose).

Before taking Tylenol, tell your doctor or pharmacist if you have liver disease or are taking warfarin (blood-thinning medicine). Children or teens recovering from chickenpox or flu-like symptoms should not take this medication.

giving Tylenol and acetaminophen to children


Symptoms of liver toxicity from an overdose of Tylenol include jaundice or yellowing of the skin and whites of the eyes, confusion, or liver failure. In some severe cases, liver damage can lead to death. If your liver has been damaged by overuse of acetaminophen, other symptoms that may occur include:

  • stomach ache
  • nausea and vomiting
  • fatigue
  • excessive sweating
  • dark urine and stool
  • pale complexion

If you experience any of these symptoms and think you have taken too much Tylenol, seek medical attention right away.

Concerns about Tylenol overdose or poisoning


Do not take more than 3 grams of Tylenol per day. If you take more, your liver may become overwhelmed and begin to fail. This can be life-threatening. Seek immediate medical attention if you start to show signs of liver toxicity, such as abdominal pain, dark urine or stool, or excessive sweating.


Tylenol (the brand name for acetaminophen) and meloxicam (a nonsteroidal anti-inflammatory drug) can be taken together to relieve pain and other symptoms of arthritis. However, if you take too much of either drug, you are at risk of serious liver damage, stomach problems, kidney failure, and even death.

Tylenol and meloxicam seem harmless because they are commonly used. And, generally speaking, they are only helpful when used appropriately, but overdose is also possible. Problems are more likely if you take other forms of NSAIDs or acetaminophen with Tylenol and meloxicam. Call your doctor right away if you think you have taken too much of these medicines.

VigorTip words

In the case of a chronic medical condition such as arthritis, pain relief is essential when living your daily life as normally as possible. Although it is generally safe to take meloxicam and Tylenol together, it is important to check with your doctor before you start any new medication to make sure your health and medication history are safe for you. When used properly, pain relievers can help you get back to living as happy and healthy as possible.