How is BuSpar used as an anxiety treatment?

BuSpar (Buspirone Hydrochloride [HCL]) Is a medicine used to treat generalized anxiety disorder. BuSpar has no chemical or pharmacological relationship with other anti-anxiety drugs (such as benzodiazepines or other tranquilizers). The effectiveness of BuSpar in the treatment of generalized anxiety disorder (GAD) has been established.

Bristol-Meyers Squibb was approved by the U.S. Food and Drug Administration (FDA) in 1986 to use Buspirone (trade name BuSpar) for the treatment of GAD. However, the patent expired in 2001 and buspirone is now sold as a generic drug.

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How BuSpar works (methods of action)

Buspirone comes from the azapirone class of drugs, which includes other anti-anxiety drugs (anti-anxiety drugs) and antipsychotics. BuSpar has an effect on neurotransmitters in the brain, such as serotonin and dopamine. Specifically, it is a serotonin receptor agonist, which means it increases the action of serotonin receptors in the brain, thereby helping to relieve anxiety.

Buspirone is often used as an add-on to other drugs, such as selective serotonin reuptake inhibitors (SSRIs), for the treatment of depression or anxiety, rather than first-line treatment.

If other drugs are ineffective or involve too many side effects, BuSpar can also be prescribed. It is most commonly used to treat generalized anxiety disorder.

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Taking BuSpar

BuSpar tablets should always be taken with or without food. It is usually taken two to three times a day. The initial dose can be increased by 5 mg every 2 to 3 days, and the maximum dose generally does not exceed 60 mg.Most patients respond to doses in the 15 to 30 mg range. BuSpar works slowly, so it may take several weeks to feel the effect.

Your doctor will evaluate your condition and your response to the medication to determine the optimal length of time you should take BuSpar.

Usually, the medicine needs to be taken for a few months to a year. When your doctor decides that you should stop taking BuSpar, the dose will be gradually reduced to help avoid the potential effects of withdrawal.

Who should not take BuSpar

Buspar (Buspirone Hydrochloride) should not be taken by people who are allergic to the drug. Drug allergy refers to an immune-mediated drug reaction, with symptoms ranging from mild to severe. In case of allergies, your doctor will stop the medication.

Buspar should also be used with caution in people with impaired liver function or pre-existing diseases. Because the clearance of buspirone is mediated by liver enzymes, if the liver is not functioning normally, the blood concentration of buspirone may increase. In addition, because buspirone affects blood sugar levels, this can be a problem for diabetics.

Buspar is not recommended for breastfeeding mothers because there is evidence that it may be excreted in breast milk. Its safety during pregnancy has also not been fully studied.

medicine interactions

BuSpar may interact with many drugs. The use of buspirone with monoamine oxidase inhibitors (MAOIs) can cause blood pressure to rise.

In addition, drugs that have an effect on liver enzymes may increase or decrease the concentration of buspirone in the blood, which can cause more side effects or lack of effectiveness of the drug. For example, erythromycin can increase the concentration of BuSpar.

For these reasons, it is important that your doctor knows all the medicines you are taking before prescribing BuSpar.

In addition, it is best to avoid alcohol while taking BuSpar. Mixing alcohol with BuSpar can cause drowsiness and dizziness. More serious effects of this combination include problems with muscle control, memory, and breathing.

Negative Effects

A series of adverse reactions may occur while taking Buspar, including dizziness, nausea, headache, nervousness or excitement, and dizziness.

Other more rare but potential adverse effects include:

  • Constipation or diarrhea
  • hard to fall asleep
  • Drowsiness and fatigue
  • Dry mouth
  • Vomiting, upset stomach, stomach pain
  • Weakness or numbness

More common side effects occur in about 10% of cases, while rarer side effects occur in only about 2% of people taking the drug.Side effects are more common when the drug is first taken, and may be lessened after a few weeks.

Related risks

Although BuSpar is not as calming as many other anti-anxiety drugs, be careful when driving, operating machinery, or participating in hazardous activities. The risk of physical or psychological dependence on BuSpar is very small, and the risk of overdose is also very low.

BuSpar and social anxiety disorder

A small 1993 study showed that in a 12-week public trial, according to DSM-III-R criteria, 17 patients with generalized social phobia were treated with buspirone. (Improvement in 12 patients).However, a double-blind placebo-controlled study of 30 SAD patients in 1997 showed no improvement compared to placebo.

These results indicate that buspirone as a single treatment option may be helpful for social anxiety disorder that is not accompanied by other diagnoses. However, if you do not respond to other drugs (such as selective serotonin reuptake inhibitors (SSRI)), buspirone may be an option for your current treatment plan.

Alternatives to BuSpar

If BuSpar does not relieve your anxiety, or you are unable to take it due to a medical condition or drug interaction, your doctor can determine the best alternative medicine or treatment based on your condition. These may include therapies such as benzodiazepines, SSRIs, or cognitive behavioral therapy (CBT).

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If you are taking BuSpar due to anxiety, be sure to follow your doctor’s instructions and report any adverse reactions. If you find that the drug has no effect on your symptoms after a few weeks, it may be worth asking your doctor if another drug is a better option.


How is BuSpar used as an anxiety treatment?
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