How long does the withdrawal from Cymbalta last?

Cymbalta (duloxetine) is a prescription medicine used to treat depression, anxiety, fibromyalgia, and diabetic neuropathy. It is the so-called serotonin and norepinephrine reuptake inhibitor (SNRI). SSNRIs have a powerful effect on the brain and help increase the activity of neurotransmitters called serotonin and norepinephrine. After stopping SNRI, some people will experience withdrawal symptoms.


When you quit Cymbalta, your brain may take some time to adjust to the absence of it. During this time, you may notice some dizziness and flu-like symptoms. Headaches, nausea, and vomiting are common in the days and weeks after you took Cymbalta for the last time. More distressing symptoms include nightmares or disturbing dreams, and a sensation of needles throughout the body.

Although these symptoms are usually mild, they can be shocking when they appear suddenly. Most people are not warned that they may have withdrawal symptoms when they stop taking antidepressants. If your doctor did warn you, they may have used the term “antidepressant withdrawal syndrome”, which may be a bit misleading.

A pooled analysis of six different placebo-controlled studies found that 44.3% of quitters reported withdrawal symptoms, compared to 22.9% in the placebo group. The most common symptom is dizziness, followed by nausea and headache.

Most participants in the Duloxetine (Cymbalta) study classified their symptoms as mild or moderate. Among people with withdrawal symptoms, about 65% said their symptoms disappeared within about a week.

Signs and symptoms

When you stop taking Cymbalta, your brain must adjust to lower levels of serotonin and norepinephrine. It may take days or weeks for your brain to adjust to the new normal. During this time, you may experience many symptoms, including:

  • Dizziness
  • Nausea
  • Vomit
  • On pins and needles
  • Nightmare
  • anxiety
  • Strange feelings, such as concussion
  • Trouble sleeping
  • irritability
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Symptoms usually appear within two to four days after stopping taking the drug and last for several weeks.Although gradually reducing (slowly reducing) the dose is a common treatment strategy, some studies have shown that even with this strategy, you may still experience some withdrawal symptoms.

Compared with other SNRIs such as venlafaxine, Cymbalta withdrawal is relatively mild.If you have read articles about SNRI’s strong withdrawal syndrome elsewhere, the author is probably referring to venlafaxine (Effexor).

There is a report of withdrawal episodesAnd a report about withdrawal symptoms recurring within ten months.

Response and relief

To make Cymbalta fall off more easily, your doctor may recommend a taper that lasts at least two weeks. Gradually reducing the dose of medication means working with your doctor to make a plan to gradually reduce the dose of medication over a longer period of time. It is not clear whether the slow gradual reduction of Cymbalta will always prevent withdrawal symptoms, but it is generally considered the safest way to stop taking antidepressants.

Work with your doctor to develop a tapering schedule that suits your needs. Your doctor may want you to switch to other antidepressants or provide medical support for your withdrawal symptoms. Other ways to ease the withdrawal experience include:

  • Work with a therapist. Talking therapy can help relieve anxiety, relieve irritability, and even reduce physical discomfort.
  • Seek support from friends and family. Letting your loved ones know that you are experiencing withdrawal symptoms can help prevent conflict and reduce confusion.
  • Practice self-care. It is important to keep your body and brain in good condition by eating healthy and exercising at least 3 times a week.
  • Try herbal remedies. If you have sleep problems, try taking over-the-counter supplements such as valerian root or melatonin before going to bed.
  • Treat pain and nausea. You can use over-the-counter pain relievers and anti-nausea medications to treat headaches and stomach pains.
  • Avoid recurrence. If you see signs of depression or anxiety recurring, discuss alternative treatment options with your doctor.
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Although quitting Cymbalta cold turkey is rarely dangerous, it is best to consult your doctor before attempting to do so. Tell your doctor why you are interested in quitting smoking and ask about diminishing options.

Long-term treatment

After Cymbalta, you may need continuous treatment. The nature of the treatment will depend on many factors, including your mental health and the reason you stopped taking the medicine.

Unlike other drugs (such as antibiotics) that are effective for almost everyone, antidepressants can be really luck. A medicine called a life-saving medicine by your friends may make you dizzy and unable to play with your child, or make you dizzy and unable to work.

Brain chemistry is an extremely complex system that involves not only neurotransmitters such as serotonin, but also nerve cells, genes, and brain structure. If the knob of one neurotransmitter is turned up, and the knob of another neurotransmitter is turned down, it is much easier to treat depression. In other words, if Cymbalta does not work for you, ask your doctor to recommend other products. Treating depression may require a process of trial and error.

If you quit Cymbalta because you feel your depression has resolved, that’s great. But it is important that you keep in touch with your psychiatrist or therapist to make sure that stopping the medication will not cause your depression to reappear. Depression is a disease with a very high recurrence rate.

Approximately 50% of people who recover from a depressive episode will have more depressive episodes in their lifetime. If you have more than one plot, there is about 80% chance that you will have another plot.

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If you have had one or more major depressive episodes, you may be a good candidate for maintenance treatment. Usually, this means continuing to take therapeutic doses of antidepressants to reduce the risk of recurrence. Other forms of maintenance therapy include psychotherapy. At the same time, pay attention to the symptoms of recurrence of depression. Common symptoms include:

  • Feeling sad, empty or hopeless
  • Experience tearfulness, anger, or frustration
  • Loss of interest, pleasure, or excitement in pleasant activities
  • Sleep too much or too little
  • Always feel tired
  • Feeling worthless or guilty
  • Focus on perceived failure or error
  • Feeling anxious, agitated, or upset
  • Move slowly, talk or think
  • Thoughts of death or suicide


If your doctor does not help, consider finding a new psychiatrist, psychologist or therapist in your area. The Substance Abuse and Mental Health Services Administration (SAMHSA) has a searchable directory of qualified providers. You can also call them at 1-800-662-HELP (4357).

If you have health insurance, you can also search the company’s list of local providers that accept your insurance.

Very good sentence

If you gave Cymbalta a good try, but you still don’t feel like yourself, please don’t give up. You can try other drugs, dosages, and drug combinations. If you think you no longer need medication, that’s fine, but don’t neglect your mental health. A qualified therapist can help enhance the effectiveness of antidepressants and help prevent recurrence. Just like medicine, there is no almighty therapist. Keep trying until you find a combination that suits you.


How long does the withdrawal from Cymbalta last?
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