Knowledge about Austedo (Ditetrabenazine)

Ostedo It is a drug used to treat involuntary movements caused by Huntington’s disease. Its role is to reduce the chemicals that cause Huntington’s disease patients to become overactive.

It is important to know that Austedo cannot cure Huntington’s disease, nor can it effectively relieve other symptoms of the disease.

Austedo is currently only available as a brand-name drug, and there are currently no approved generic drugs available for purchase. The active ingredients in Austedo are Tetrabenazine It belongs to a class of drugs called selective vesicle monoamine transporter 2 (VMAT2) inhibitors.

VMAT2 inhibitors are drugs that reduce chemical messengers such as dopamine and serotonin, especially in your nerve endings.This helps treat chorea and Tardive dyskinesia.


Austedo is approved by the FDA to treat the following diseases:

  • Chorea in Huntington’s disease patients: Chorea is a disease that causes sudden involuntary muscle movement. It occurs in diseases such as lupus and hyperthyroidism, but is most closely related to Huntington’s disease.
  • Tardive dyskinesia: This is a disorder that affects the nervous system and causes uncontrollable movements of the face, lips, tongue, and sometimes even the upper body. This condition is most common in people with schizophrenia, bipolar disorder, or long-term use of antipsychotic drugs.

Before taking

People with a history of depression, liver disease, or suicidal thoughts are not encouraged to take Austedo.

Before taking this medicine, check with your doctor for the list of active and inactive ingredients contained in the medicine. If you are allergic to tetrabenazine, you should not take this medicine.

Signs of an allergic reaction include difficulty breathing, swelling of the face, tongue, or throat, and skin rashes. If you took Serpalan (reserpine) 20 days before the consultation, your doctor will not prescribe Austedo.

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There is no research showing that Austedo has an adverse effect on pregnant or breastfeeding women or their children. However, you should tell your doctor if you are pregnant or if you are likely to become pregnant before taking Austedo.

Before taking Austedo, please provide your doctor with a list of any other vitamins, supplements, and medications you are taking to ensure that they do not cause dangerous reactions when used with the medication.

Precautions and contraindications

Taking Austedo may increase the risk of depression and suicidal thoughts in people with Huntington’s disease. If you or someone you love is taking Austedo and you notice any sudden changes in mood and behavior, monitor your symptoms closely.

Any signs of suicidal thoughts or behavior should be reported to your doctor. In Huntington’s disease patients, Austedo may also worsen other symptoms of the condition, such as mood changes, stiffness, and cognitive function.

Your doctor will continuously evaluate the progress of your condition and symptoms to ensure that Austedo is safe for you.


Austedo is available in 6, 9, and 12 milligram strengths.The dosage of Austedo is provided by your doctor and tailored to your specific needs.

When deciding the best dose for you, your doctor will consider your medical history, the severity of your condition, your tolerance of the drug, and any other factors that will help them determine the best dose for you.

However, the manufacturer recommends the following dosages to treat the following conditions:

  • Chorea Related to Huntington’s disease: The initial dose is 6 mg once a day. Your dose may be increased by 6 milligrams per week and daily. The maximum dose for chorea caused by Huntington’s disease is 48 mg per day.
  • Tardive dyskinesia: An initial dose of 6 mg taken twice a day is used to treat this condition. Your doctor may steadily increase this based on your response to the medication and whether you are experiencing serious side effects.
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People taking strong CYP2D6 inhibitors such as fluoxetine and quinidine should not take more than 36 mg per day. They should not take more than 18 mg of Austedo in a single dose.

CYP2D6 is an enzyme that helps in the metabolism of certain drugs. CYP2D6 inhibitors will reduce the activity of this enzyme.

How to take and store

You can only take Austedo in the way prescribed by your doctor. If you are not sure what to do, you can refer to the prescription label. Austedo is usually taken with food and water. Before taking the medicine, you should not chew, break or crush the medicine, but swallow it whole.

Store the container with the pills at room temperature. Keep it away from humid environments (such as bathrooms) and direct sunlight.

If you miss a dose, take it as soon as you remember. If it is close to the time of your next medication, skip the missed dose and take your next medication.

side effect

When using Austedo, you may experience some side effects. In some cases, these side effects may not be caused by the medication, but by your condition. This is why it is important to share any new, developing or worsening side effects with your doctor.

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Some of the common and minor side effects you may experience while using this drug include:

  • Dry mouth
  • Insomnia
  • diarrhea
  • fatigue
  • drowsiness
  • Inflammation of the nose and throat

These side effects may disappear after a few weeks, but if they do not disappear or become more serious, consult your doctor.


It is not common to have serious side effects when using Austedo. However, in rare cases, the following side effects may occur:

  • Antipsychotic malignant syndrome (NMS), which can cause symptoms of fever, muscle pain, fatigue, confusion, and irregular heartbeat
  • Frustrated
  • Over-fatigue
  • Suicidal thoughts
  • Parkinson’s disease (Symptoms include tremors, difficulty moving, stiffness, and falls)
  • Hyperprolactinemia
  • Arrhythmia

Warning and interaction

Austedo is not approved for use by people 18 years of age or younger. Austedo may impair your thoughts and reactions, which is why you should avoid driving or operating any heavy machinery shortly after taking this medication. Drinking alcohol is also not recommended when taking this drug, as it may cause adverse reactions.

If you use drugs for heart disease, asthma, high blood pressure, depression, or cancer while using Austedo, your risk of heart disease may increase.

One of the side effects of Austedo is drowsiness, which can be exacerbated by using this drug with other drugs that may make you drowsy. According to reports, MAOIs such as linezolid, phenelzine, and isocarboxazid can also interact dangerously with Austedo.

If a person shows signs of an Austedo overdose, please call 911 immediately. Signs of overdose include muscle stiffness, drowsiness, sweating, and muscle pain.