Caplyta (lumateperone) is an atypical antipsychotic drug used to treat adult schizophrenia. Schizophrenia is a lifelong brain disease that can cause symptoms such as delusions, hallucinations, speech confusion, and changes in emotional expression.
Caplyta is taken as a capsule once a day. The exact mechanism of action is not fully understood, but it is believed that the drug can act as an antagonist of certain serotonin and dopamine receptors.In clinical trials, the drug has been shown to improve the symptoms of schizophrenia.No generic version of the medicine is available.
Caplyta is approved for the treatment of adult schizophrenia. Caplyta affects dopamine, serotonin, and glutamate to improve symptoms that affect mood, thoughts, and behavior.
This drug may help relieve some of the symptoms of schizophrenia, thereby improving the functions of daily life. Some symptoms of schizophrenia include:
It was first approved by the U.S. Food and Drug Administration for the treatment of schizophrenia on December 20, 2019.
Caplyta can also be prescribed off-label to treat other mental health conditions. When a drug is prescribed off-label, it means that it has not been approved by the FDA for that use. However, if your doctor thinks the medicine may help your condition, they may choose to prescribe it.
For example, other atypical antipsychotics are sometimes prescribed off-label to treat conditions such as bipolar disorder, attention deficit hyperactivity disorder (ADHD), anxiety and depression.
Caplyta is currently being evaluated for the treatment of bipolar disorder, Behavioral disorders in patients with dementia, depression, and other neurological diseases. However, its safety and effectiveness for these conditions have not yet been determined.
If you think Caplyta might be right for you, be sure to consult your doctor. Before prescribing this medicine, your doctor will first need to evaluate your symptoms and make a diagnosis. This also means that your doctor needs to rule out other conditions that may cause you to develop symptoms.
Your doctor may decide to prescribe Caplyta based on your personal symptoms, potential side effects, and your past reactions to other schizophrenia medications.
Be sure to discuss any other medications or supplements you are currently taking with your doctor. Some may cause drug interactions, which may be dangerous or affect the efficacy of any kind of drug.
Precautions and contraindications
People who are known to be sensitive to lumateperone or other ingredients of Caplyta should not take this medication. It should not be used to treat psychosis related to dementia.
Antipsychotic drugs such as Caplyta may also increase the risk of antipsychotic malignant syndrome (NMS), which can be fatal and cause symptoms including autonomic instability, delirium, high fever, and muscle stiffness.
If a person develops such symptoms, Caplyta should be stopped immediately, and related symptoms should be closely monitored and treated.
According to the prescription information, Caplyta can be used as a 42 milligram (mg) strength capsule.All listed dosages are provided by the drug manufacturer. Check your prescription and talk to your doctor to make sure you are taking the correct dose.
How to take and store
It should be taken with food once a day. Medications should be stored at room temperature between 68°F and 77°F. This medicine can be taken while traveling, but should be kept between 59°F and 86°F when going out.
If you forget to take your medicine, take it as soon as possible, but if your next medicine time is approaching, skip the missed dose. Do not take two doses at the same time.
Caplyta may cause some side effects.
The two most common side effects of Caplyta are dry mouth and drowsiness.
Some of the more serious side effects that may occur while taking Caplyta include:
- Blood pressure drops when standing, which may cause loss of consciousness
- Impaired ability to operate vehicles or heavy equipment
- Increased risk of falls
- Elderly people with dementia-related psychosis are at increased risk of stroke and death
- Low white blood cell count
- Tardive dyskinesia, including uncontrolled movements of the face and body
- Weight gain and high blood sugar
Some people may also experience temperature regulation problems. Be cautious when exercising vigorously, and take care to avoid dehydration and heat.
Warning and interaction
Antipsychotic drugs such as Caplyta are associated with metabolic changes, such as diabetes and hyperglycemia. In one trial, approximately 4.7% of patients taking Caplyta had elevated A1C levels.
The symptoms of hyperglycemia, diabetes, dyslipidemia, and weight gain should be monitored at the beginning of the medication, and should be checked regularly during long-term treatment.
During treatment with Caplyta and other antipsychotics, leukopenia and neutropenia may also occur, which involves the reduction of white blood cells needed to fight infection. Fatal cases of agranulocytosis, including leukopenia called granulocytes, have also been reported to be used with other drugs of the same class.
Individuals with a history of low white blood cell count (WBC) should be monitored, and Caplyta should be discontinued if WBC drops significantly.
Caplyta provides a black box warning of adverse cerebrovascular reactions (which may include stroke) in elderly patients with dementia-related psychosis.
You should avoid taking Caplyta with CYP3A4 inducers, moderate or strong CYP3A4 inhibitors, and UGT inhibitors. Taking these drugs together increases the risk of adverse reactions. Medications that may cause interactions include:
- Valproic acid
You should also avoid taking Caplyta with grapefruit juice and St. John’s wort. Avoid using drugs or alcohol while taking Caplyta, as these substances may reduce the effectiveness of the drug and increase the risk of side effects such as sedation.
Before you start taking Caplyta, be sure to tell your doctor about any medications, supplements, or substances you are currently taking.
Taking Caplyta in the third trimester of pregnancy may cause withdrawal symptoms or extrapyramidal symptoms in the baby. There is no estimate of the risk of miscarriage or birth defects from taking Caplyta. You should discuss the risks and benefits of taking this medication during pregnancy with your doctor.
Always take the medicine as directed by your doctor. Do not stop taking the medicine even if you feel better. If you are concerned about the side effects or other aspects of the medicine, please consult your doctor before stopping or changing the dosage.