Should I take antidepressants at night or in the morning?

Time recommendations based on side effects
side effect When to take the medicine
Insomnia morning
drowsiness Bedtime
Sexual problems morning
Nausea Bedtime
Urinary problems morning

When is it better to take it in the morning

Antidepressants are sometimes best taken in the morning because they have potential side effects. There are some considerations here.


Some selective serotonin reuptake inhibitors (SSRIs) are the most commonly used type of antidepressant. They can disrupt some people’s sleep and are best taken in the morning.

For example, the manufacturer of Prozac (fluoxetine) recommends taking it in the morning because it can make some people feel more energetic, especially at the beginning of treatment.

However, when Prozac is used in combination with Zyprexa (olanzapine) (a combination called Symbyax) to treat refractory depression, it can cause drowsiness, so it is recommended to take it at night.

Paxil (paroxetine) is usually taken in the morning to prevent sleeplessness at night. However, if it is found to cause drowsiness, you can take it before going to bed. Wellbutrin (bupropion) is another antidepressant and is recommended to be taken in the morning to prevent nighttime insomnia.

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Urinary problems

When prescribed in children or adolescents, Zoloft can cause frequent urination and incontinence. In this case, taking birth control pills in the morning can prevent bedwetting at night.

Sexual problems

If you experience sexual side effects (such as low libido, erectile dysfunction, or inability to ejaculate) due to taking antidepressants, the timing of taking the antidepressants will be different.

Studies have shown that it may be helpful to consider the time of day when you are most likely to be sexually active and plan to take antidepressants shortly thereafter.of

When is best to take at night

If antidepressants are taken near bedtime, some side effects will be better tolerated. These are some of the influences that fall into this category.


Unlike some SSRIs, certain other antidepressants tend to make you feel drowsy, so if you take them before bedtime, they will be better tolerated. These drugs include Luvox (fluvoxamine), Remeron (mirtazapine) and tricyclic antidepressants,include:

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  • Ilavir (amitriptyline)
  • Nopmine (desipramine)
  • Tofranil (imipramine)
  • Pamelo (nortriptyline)


Certain classes of antidepressants (mainly SSRIs) can cause nausea, vomiting, diarrhea, and loss of appetite. Although this usually resolves itself as your body adapts to the medication, sticking to a nightly medication schedule can also help you get through any digestive problems.

Other best medication strategies

In addition to discussing the best time to take antidepressants with your doctor, it is important to remember that there are other strategies that affect the effectiveness of your medications, including:

Be patient

Antidepressants take time to work; it may take 6 to 12 weeks to fully work,Although many people will notice improvement within a week or two. When you start taking antidepressants, keep in close contact with your doctor and maintain a positive attitude. You can find a way to treat your condition, but this may require some trial and error.

be consistent

Take antidepressants as directed at the same time each day, and don’t stop taking them without first consulting your doctor.

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Talk to your doctor

If your antidepressants cause side effects, remember that many, if not all, will disappear over time. If the side effects are unbearable, please contact your doctor immediately. Seeking relief may be as simple as changing the dose, switching to a different antidepressant, or adding a second drug to reduce the side effects.

Very good sentence

Taking antidepressants needs to be part of a well-thought-out plan with your doctor to maximize their benefits and minimize any potential side effects. Please do not make any changes to your treatment plan without consulting your doctor first.

The recommendations mentioned above are general and may or may not apply to your own unique situation. Your doctor will be able to provide you with specific advice on whether antidepressants should be taken at specific times of the day for best results.