What is cannabidiol (CBG)?
Cannabidiol (CBG) is a cannabinoid extracted from the cannabis plant. It is often referred to as the mother of all cannabinoids. This is because other cannabinoids come from cannabidiol acid (CBGA), an acidic form of CBG.
Other more common cannabinoids extracted from the cannabis plant include cannabidiol (CBD) and Tetrahydrocannabinol (Tetrahydrocannabinol).
The content of CBG in cannabis plants is lower than other cannabinoids. In most strains of plants, only 1% of CBG can be found compared to 20% to 25% of CBD or 25% to 30% of THC.
This makes consumer products derived from cannabinoids rare and often expensive. However, CBG is gaining popularity due to the many potential benefits that cannabinoids must provide.
How is CBG made
CBG is derived from young cannabis plants because they contain more CBG than fully developed plants.
Some cannabis varieties, such as White CBG, Super Glue CBG and Jack Frost CBG, have higher CBG content than other varieties. These strains are specially cultivated to produce more CBG.
Both CBD and THC start with CBGA, which is the acidic form of CBG. This is why young cannabis plants contain higher concentrations of CBG.
In fully developed plants with high concentrations of THC and CBD, you will find very low concentrations of CBG. This happened because with the development of the factory, most of the CBG has been converted to CBD and THC.
Due to the difficulty of obtaining CBG, cannabis growers have been trying hybrid breeding and genetic manipulation to help cannabis plants produce more CBG.
How CBG works
CBG is processed by the body’s endocannabinoid system. The endocannabinoid system is composed of molecules and receptors in our body, which are responsible for keeping our body in top condition regardless of what happens in our external environment.
In our body, CBG imitates Endocannabinoids, A natural compound produced by our body.
Cannabinoid receptors in the body
Our body contains two cannabinoid receptors-CB1 and CB2. CB1 receptors are located in the nervous system and brain, while CB2 receptors are located in the immune system and other parts of the body.
CBG works by binding to two receptors. It is believed that it can enhance the function of anandamide. Anandamide is a neurotransmitter that can enhance pleasure and motivation, regulate appetite and sleep, and relieve pain. Unlike THC, CBG has no mental effect, so it will not give you high feelings.
Potential benefits of CBG
Like CBD, CBG has been used to fight pain without the narcotic effects of cannabinoids like THC.
Studies have shown that CBG also has a therapeutic effect. However, there are few human studies in this area, and more research is needed in this area.
Some promising animal studies indicate that CBG may eventually be found to be useful for the following treatment benefits.
Inflammatory bowel disease (IBD)
Inflammatory bowel disease is a disease that causes chronic inflammation of the intestinal tract. It affects millions of people around the world and there is no cure.
An experimental animal study conducted in 2013 observed the beneficial effects of CBG on inflammatory bowel disease.
The researchers induced inflammation similar to IBD in the mouse colon and then administered CBG. It was found that CBG can reduce inflammation and the production of nitric oxide. It also reduces the formation of reactive oxygen species (ROS) in the intestine. They concluded that CBG should be considered for clinical trials in patients with IBD.
In an animal study, researchers discovered that CBG has the potential to treat glaucoma.
Researchers administered CBG to cats with glaucoma and found that the intraocular pressure decreased and the outflow of aqueous humor increased. The outflow of aqueous humor is a kind of fluid produced by the eyes that can maintain intraocular pressure and provide nutrients to the eyes.
Huntington’s disease is a disease that causes the breakdown of nerve cells in the brain. In a 2015 study, researchers examined the potential neuroprotective properties of CBG and other cannabinoids in mice with experimental Huntington’s disease models.
It has been observed that CBG acts as a neuroprotective agent, protecting nerve cells in the brain from damage. It can also improve motor deficits and protect striatal neurons from the effects of 3-nitropropionic acid toxicity.
A 2020 study on the potential of cannabis antibiotics found that CBG has antibacterial properties. Especially for the methicillin-resistant strain of Staphylococcus aureus (MRSA), which is a drug-resistant bacteria that causes Staphylococcus infection.of
Fight against cancer cells
In a 2014 study, researchers observed the effect of CBG on rats with colon cancer. They observed that CBG showed some promise in blocking the receptors that lead to the growth of cancer cells and inhibiting the growth of colorectal cancer cells.
They suggest that CBG should be considered in the treatment and prevention of colon cancer.of
How to use CBG
The most common way to produce CBG for consumers is as oil. You can get the benefits of CBG by using pure CBG oil. However, CBG oil is rare and expensive.
The good news is that you can also get some of the benefits of CBG from using broad-spectrum CBD oil. Broad-spectrum CBD oil contains all the cannabinoids found in the hemp plant, including CBG, but not THC.
When cannabinoids are used together, they can increase each other’s effectiveness through a phenomenon called the entourage effect.
CBG and CBD
CBG is often compared to CBD because it has many similarities and they both act on the endocannabinoid system.
Both CBG and CBD are non-psychoactive, which means they will not change your mindset like THC.
However, if you consume cannabis plants, they can reduce the mental effects of THC. One of the biggest differences between CBD and CBG is the amount found in most cannabis plants. Most hemp plants contain only 1% CBG, but up to 25% CBD.
CBG interacts with our endocannabinoid system in a different way than CBD. CBG binds directly to the CB1 and CB2 receptors and may be more effective in delivering its benefits to our system.
The difficulty of CBG production makes it very scarce. It is more difficult to produce than other cannabinoids such as THC and CBD. Since CBG and CBD have many similarities, manufacturers prefer to produce CBD.
When CBG is produced, the products derived from it are very expensive. However, CBG has many promising potential benefits, and more research is underway to simplify the production and supply of cannabinoids.